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Thursday, April 30, 2020 | History

1 edition of Bispecific antibodies and targeted cellular cytotoxicity found in the catalog.

Bispecific antibodies and targeted cellular cytotoxicity

Bispecific antibodies and targeted cellular cytotoxicity

Ostuni (Brindisi), Italy, June 13-17, 1992

by

  • 333 Want to read
  • 24 Currently reading

Published by Published for the UICC by Wiley-Liss in [New York] .
Written in English

    Subjects:
  • Immunoglobulins.,
  • Antibody-dependent cell cytotoxicity.

  • Edition Notes

    Other titlesTargeted cellular cytotoxicity., Cellular cytotoxicity.
    Statementchairpersons: R.L.H. Bolhuis, M.I. Colnaghi.
    SeriesIntenational journal of cancer. Supplement -- 7 = -- Journal international du cancer. Supplement, International journal of cancer -- no. 7.
    ContributionsBolhuis, R. L. H., Colnaghi, M. I., International Union against Cancer.
    The Physical Object
    Pagination81 p. :
    Number of Pages81
    ID Numbers
    Open LibraryOL15190800M


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Bispecific antibodies and targeted cellular cytotoxicity Download PDF EPUB FB2

The Second International Conference on Bispecific Antibodies (BsAbs) and Targeted Cellular Cytotoxicity considered how targeted cytotoxicity can be used (1) to increase understanding of the general mechanisms of cellular cytotoxicity and (2) clinically in the Cited by: BsAbs, the main mediators of targeted cellular cytotoxicity, can be made by chemical crosslinking, by fusing hybridoma cells and by molecular genetic approaches.

BsAbs bind to target cells via one V region and trigger molecules such as T-cell receptors (TCRs) or FcR for IgG (Fc gamma R) on cytotoxic cells via their other V by: BsAbs, the main mediators of targeted cellular cytotoxicity, can be made by chemical crosslinking, by fusing hybridoma cells and by molecular genetic approaches.

BsAbs bind to target cells via one V region and trigger molecules such as T-cell receptors (TCRs) or FcR for IgG (FcyR) on cytotoxic cells via their other V by: Bispecific Antibodies Bispecific antibodies and targeted cellular cytotoxicity book Targeted Cellular Cytotoxicity: Therapeutic Hopes Confirmed Bispecific Antibodies and Targeted Cellular Cytotoxicity: Therapeutic Hopes Confirmed Bauer, Thérèse; Drakeman, Donald L.

Thkrise Bauera, Donald L. Drakeman T e n t r e National de Transfusion Sanguine, Paris, France: bMedarex, Princeton, N. J., USA Gathering in France, scientists. Bispecific antibodies for targeted celiular cytotoxicity Michael W.

Fanger and Paul M. Guyre Bispecific antibodies have the ability to redirect normal cytotoxic mechanisms to kill tumors or pathogens and thus represent a potentially powerful tool for the therapy of cancer and infectious by: Bispecific antibodies for targeted celiular cytotoxicity Michael W.

Fanger and Paul M. Guyre Bispecific antibodies have the ability to redirect normal cytotoxic mechanisms to kill tumors or pathogens and thus represent a potentially powerful tool for the therapy of cancer and infectious disease. FASEB J. Aug;4(11) Going both ways: bispecific antibodies and targeted cellular cytotoxicity.

Fanger MW, Segal DM, Bispecific antibodies and targeted cellular cytotoxicity book by: For example, bispecific molecules targeting TNF and IL are in preclinical development for the treatment of IBD and other autoimmune/inflammatory diseases [52,53].

In a CDinduced colitis model, a murine BsAb targeting IL showed synergistic efficacy relative to antibodies against TNF and IL alone [52,53].Cited by: 6. In: Bispecific Antibodies and Targeted Cellular Cytotoxicity, ’ Second International Conference, Seillac, France.

October 9–13,Romet-Lemonne JL, Fanger MW, Segal DM, eds. Fondation Nationale de Transfusion Sanguine, Les Ulis, France. – Google ScholarCited by: 5. Recent studies have shown that human T cells can be targeted with bispecific antibody to react against human tumor cells in vitro.

We have developed a bispecific F(ab')2 antibody molecule consisting of a humanized arm with a specificity to pHER2 linked to another arm derived from a murine anti-CD3 monoclonal antibody that we have cloned from UCHT1 hybridoma.

Bispecific antibodies have the ability to redirect normal cytotoxic mechanisms to kill tumors or pathogens and thus represent a potentially powerful tool for the therapy of cancer and infectious by:   Monoclonal anti-tumor antibodies (mAbs) that are clinically effective usually recruit, via their constant fragment (Fc) domain, Fc receptor (FcR)-positive accessory cells of the immune system and engage these additionally against the tumor.

Since T cells are FcR negative, these important cells are not getting involved. In contrast to mAbs, bispecific antibodies (bsAbs) can be designed in such Cited by: In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats.

The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting. • Since most of the bispecific antibodies mediated targeting of tumor cells is through T cells, the potency of activated T cells must be balanced against CRS.

• Development of advanced technological platforms provide opportunities to design BsAbs to address issues Cited by: Bispecific antibody based therapeutics: Strengths and challenges Blood Reviews, Vol.

32, No. 4 Trispecific antibodies for CD16A-directed NK cell engagement and dual-targeting of tumor cellsCited by: In this book, the different means of generating bispecific antibodies are described, with an emphasis on recombinant formats, and information on the various applications of bispecific antibodies.

Third international conference on bispecific antibodies and targeted cellular cytotoxicity International Journal of Clinical and Laboratory Research vol page 62 () Cite this article 15 Accesses. Bispecific T-cell engager (BiTE) antibodies are a novel subclass of therapeutic single-chain antibodies.

What distinguishes BiTE antibodies from prior antibody-based therapeutics is that the effector is a cytotoxic T cell rather than a conjugated radioactive isotope, cytotoxic chemotherapy agent, or antibody-dependent cellular cytotoxicity. Early results from clinical studies with a Cited by: The Fc receptor mediated antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis induced by bispecific antibody (BsAb) to the high-affinity Fc receptor for IgG (Fc gamma RI) and to human red blood group antigen RhD were studied in vitro, using human mononuclear leucocytes as Cited by: 8.

Third International Conference on Bispecific Antibodies and Targeted Cellular Cytotoxicity, Rosa Marina Hotel, Ostuni Brindisi, Italy, 13–17 June Biotherapy volume 4. Bispecific antibodies (BsAbs) recognize two different epitopes.

This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathways simultaneously, dual targeting of different disease mediators, and delivering payloads to targeted sites.

The approval of catumaxomab (anti-EpCAM and anti-CD3) and blinatumomab (anti Cited by: Bispecific and Biparatopic Antibody Drug Conjugates keeping Fc-related effector functions such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, antibody.

Monoclonal antibody therapeutics have proven to be successful treatment options for patients in various indications. Particularly in oncology, therapeutic concepts involving antibodies often rely on the so-called effector functions, such as antibody dependent cellular cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC), which are programed in the antibody Fc by: 3.

One example is AFM13, a CD30–CD16A bispecific compound in the tetravalent TandAb format. 48 CD16A, or FcγRIIIA, is an FcγR expressed by NK cells and macrophages.

23,24 Upon binding to the Fc domain of an antibody attached to its cognate antigen, CD16A induces antibody-dependent cellular cytotoxicity (ADCC) of the antigen-expressing cell. 49 Cited by: The in vivo half-life, antibody-dependent cellular cytotoxicity function, and binding ability to Fcgamma receptors and C1q of the test oligospecific antibodies remain similar to the corresponding.

The tetramerized bispecific antibody targeted EGFR and CD16 simultaneously and then exhibited cytotoxicity against EGFR-expressing tumor cells. MDX is a bispecific antibody that combined humanized Fab anti-FcγRI (CD64) and humanized Fab anti-EGFR [ 88 ].Cited by: A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.

Bl – (). Article. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology [01 Aug4(11)]Cited by: With the current biotherapeutic market dominated by antibody molecules, bispecific antibodies represent a key component of the next-generation of antibody therapy.

Bispecific antibodies can target two different antigens at the same time, such as simultaneously binding tumor cell receptors and recruiting cytotoxic immune cells.

Structural diversity has been fast-growing in the bispecific Cited by: 5. Bispecific antibodies, which are engineered to engage a cancer cell antigen and activate T cells to kill the cancer cell, are showing clinical promise. Unfortunately, they can also cause major side effects as a result of uncontrolled immune activation and cytokine release.

Li et al. found a way to separate the beneficial effects from the harmful ones by showing that activation of tumor Cited by: 3. A bi-specific antibody that binds both T cells and a tumor-specific intracellular antigen shows therapeutic promise in mouse models of cancer.

Intracellular tumor antigens presented on Cited by: Based on years of experience in antibody discovery and production, Creative Biolabs has developed second to none antibody analysis our comprehensive analysis platform, we are proud to offer antibody-dependent cellular phagocytosis (ADCP) assays for bispecific antibodies (BsAbs) and other therapeutic antibodies.

Journal: International journal of cancer. Supplement = Journal international du cancer. Supplement[/12]. of bispecific antibodies 4. Bispecific T cell engagers (BiTEs) redirect T cells against of maintaining targeted specificity.

The overall challenge, then, is to develop safer, more spe- exploit the cytotoxic potential of the cellular immune response and circumvent mechanisms of tumor evasion, but are also manufactured with relative ease.

Bispecific Antibodies Add Bispecific Monoclonal Antibodies Add Pharm Action Immunologic Factors Registry Number 0 CAS Type 1 Name NLM Classification # They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to.

Activity of Antibody-Engaged T Cells against Large Tumors and Disseminated Disease. The first clinical results with CD3/CDbispecific BiTE antibody blinatumomab from ongoing phase 1 and 2 studies have confirmed that T cells can be potently engaged within cancer patients for redirected tumor cell lysis (11, 12).The BiTE antibody showed activity as a single-agent therapy in treating bulky Cited by: Bispecific T-cell engager (BiTE) antibodies are a novel subclass of therapeutic single-chain antibodies.

What distinguishes BiTE antibodies from prior antibody-based therapeutics is that the effector is a cytotoxic T cell rather than a conjugated radioactive isotope, cytotoxic chemotherapy agent, or antibody-dependent cellular cytotoxicity.

Early results from clinical studies with a Cited by: Heterodimeric Bispecific Single-Chain Variable-Fragment Antibodies Against EpCAM and CD16 Induce Effective Antibody-Dependent Cellular Cytotoxicity Against Human Carcinoma Cells. Daniel A.

Vallera, Bin Zhang, Michelle K. Gleason, Seunguk Oh, Louis M. Weiner, Dan S. Kaufman, Valarie McCullar, Jeffrey S. Miller, and ; Michael R. VernerisCited by:   – Five international conferences on bispecific antibodies and targeted cellular cytotoxicity.

Within the short period of four years afterthe bispecific movement had gained so many followers that the leaders of the ADCC field, Michael W.

Fanger and David M. Segal, could convene a “First International Conference on Targeted Cellular Cytotoxicity and Bispecific Antibodies Cited by: A full-length IgG1 bispecific antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) directed against human epidermal growth factor receptor 2 (HER2; EGFR2, ERBB2) and human epidermal growth factor receptor 3 (HER3; ErbB3), with potential antineoplastic activity.

Upon intravenous administration, the bispecific antibody docks on HER2, and subsequently blocks heregulin. T-cell bispecific antibodies. T-cell bispecific antibodies are constructed by joining two identical light and heavy chains of two different monoclonal antibodies, creating two distinct antigen binding sites (Fab regions) with a common Fc structure allows simultaneous binding to T cells and selected tumor cell surface antigens, which redirects the cytotoxic activity of T cells to.

Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the anti-cancer effects of ta.Neutrophils are generally not considered as potential effector cells.

However, the most abundant population of circulating white blood cells consists of neutrophils, which express Fc receptors for both immunoglobulin (Ig) G and IgA. In the presence of mAbs that are directed against tumour cells, they execute potent cytotoxic functions.